Recent updates to the Windows 10 operating system have rendered some installs of Windows Mobile Device Center unusable.
In order to fix these issues, you can do a couple of things. First you will want to make sure the .NET Framework 3.5 is enabled, and you may have to add a couple of registry entries.
This support note will walk you through the steps, if needed.
The executable file found here can add the registry entries for you with ease. Just download the tool and run it as an administrator to add the entries. You will want to reboot your computer after the entries are added.
If you are still having trouble connecting, you can try turning off the “Advanced Network Functionality” on the device by going to Settings>Connections>USB to PC and un-checking the box. You may also want to try re-installing WMDC after the registry updated and .NET framework has been fully activated. A reboot of the computer can help get connected as well.
Let us know if you re still having issues!